upset 6 antonyms and opposites of upset. Adj — Unhappy, distressed, or annoyed. Synonyms for upset in a tizzy agitate freak bother bring down discompose disconcert enturbulate disturb mortify perturb put out ruffle throw off balance unsettle flurry Antonyms for upset alleviate appease calm comfort compose quieten ← Back to the full definition of upset