gist 0 antonyms and opposites of gist. Noun — The main point or essential meaning of something longer or more complicated. Synonyms for gist bowels sum brass tacks core crux essence drift guts gravamen heart heart and soul heartstring heartstrings inwardness kernel marrow meat moral of the story nitty-gritty nub nuts and bolts pith punctum saliens quintessence soul spirit stuff substance tenor ← Back to the full definition of gist